Which symptom is commonly associated with vaccines administered intranasally?

Which symptom is commonly associated with vaccines administered intranasally?

• A. Fever
• B. Cough
• C. Headache
• D. Runny nose

Answer: (D)

Intranasal vaccines target the nasal mucosa, so the most common symptom is a local nasal reaction from irritation and increased mucus production. The nasal lining responds to the vaccine components with mild inflammation that boosts mucus secretion, leading to a runny nose. Fever is a more systemic response and isn’t as typical for nasal administration, while cough or headache can occur but are less directly tied to delivering the vaccine through the nose.

Intranasal vaccines target the nasal mucosa, so the most common symptom is a local nasal reaction from irritation and increased mucus production. The nasal lining responds to the vaccine components with mild inflammation that boosts mucus secretion, leading to a runny nose. Fever is a more systemic response and isn’t as typical for nasal administration, while cough or headache can occur but are less directly tied to delivering the vaccine through the nose.